High affinity TGF.beta. nucleic acid ligands and inhibitors

Details High affinity TGF.beta. nucleic acid ligands and inhibitors High affinity TGF.beta. nucleic acid ligands and inhibitors

1998-03-23

2000-09-26

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 912, 536 231, 536 254, C07H 2104

Patent

active

06124449&

ABSTRACT:
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.. Included in the invention are specific RNA ligands to TGF.beta.1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.1 with its receptor.

REFERENCES:
patent: 5270163 (1993-12-01), Gold et al.
patent: 5459015 (1995-10-01), Janjic et al.
Arteaga et al. (1993) J. Clin. Invest. 92:2569.
Arteaga et al. (1990) Cell Growth & Differentiation 1:367.
Barral et al. (1993) Proc. Natl. Acad. Sci. USA 90:3442.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 84.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Oliphant et al. (1986) Gene 44:177.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphand and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Robertson and Joyce (1990) Nature 344:467.
Shah et al. (1992) Lancet 339:213.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.

Affiliated with

Also associated with

Rating

High affinity TGF.beta. nucleic acid ligands and inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High affinity TGF.beta. nucleic acid ligands and inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High affinity TGF.beta. nucleic acid ligands and inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2101219