High affinity TCR proteins and methods

Details High affinity TCR proteins and methods High affinity TCR proteins and methods

2004-02-20

2009-08-04

Vogel, Nancy (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100

Reexamination Certificate

active

07569357

ABSTRACT:
T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T cell receptor mutant coding sequence into yeast cells; inducing expression of the T cell receptor mutant coding sequence on the surface of yeast cells; and selecting those cells expressing T cell receptor mutants that have higher affinity for the peptide/MHC ligand than the wild type T cell receptor protein. The high affinity TCRs can be used in place of an antibody or single chain antibody.

REFERENCES:
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3927193 (1975-12-01), Hansen et al.
patent: 3939350 (1976-02-01), Kronick et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4275149 (1981-06-01), Litman et al.
patent: 4277437 (1981-07-01), Maggio
patent: 4331647 (1982-05-01), Goldenberg
patent: 4348376 (1982-09-01), Goldenberg
patent: 4361544 (1982-11-01), Goldenberg
patent: 4366241 (1982-12-01), Tom et al.
patent: 4444744 (1984-04-01), Goldenberg
patent: 4468457 (1984-08-01), Goldenberg et al.
patent: 4640561 (1987-02-01), George
patent: 4713332 (1987-12-01), Mak
patent: 4831122 (1989-05-01), Buchsbaum et al.
patent: 4873190 (1989-10-01), Saito et al.
patent: 4874845 (1989-10-01), Saito et al.
patent: 4923799 (1990-05-01), Mak
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4970296 (1990-11-01), Saito et al.
patent: 5013650 (1991-05-01), Carty
patent: 5024940 (1991-06-01), Brenner et al.
patent: 5059413 (1991-10-01), Reardan et al.
patent: 5101827 (1992-04-01), Goldenberg
patent: 5185250 (1993-02-01), Brenner et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5225539 (1993-07-01), Winter
patent: 5258289 (1993-11-01), Davis
patent: 5258498 (1993-11-01), Huston et al.
patent: 5260203 (1993-11-01), Ladner et al.
patent: 5299253 (1994-03-01), Wessels
patent: 5316922 (1994-05-01), Brown
patent: 5316925 (1994-05-01), Davis et al.
patent: 5340921 (1994-08-01), Brenner et al.
patent: 5348867 (1994-09-01), Georgiou et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5411873 (1995-05-01), Adams
patent: 5427908 (1995-06-01), Dower
patent: 5482858 (1996-01-01), Huston et al.
patent: 5498530 (1996-03-01), Schatz
patent: 5510240 (1996-04-01), Lam
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5571698 (1996-11-01), Ladner
patent: 5580717 (1996-12-01), Dower et al.
patent: 5580961 (1996-12-01), Saito et al.
patent: 5601822 (1997-02-01), Brenner et al.
patent: 5614192 (1997-03-01), Vandenbark
patent: 5624817 (1997-04-01), Miller et al.
patent: RE35500 (1997-05-01), Rhodes
patent: 5635363 (1997-06-01), Altman et al.
patent: 5667988 (1997-09-01), Barbas et al.
patent: 5723286 (1998-03-01), Dower et al.
patent: 5723309 (1998-03-01), Bonneville
patent: 5723323 (1998-03-01), Kauffman et al.
patent: 5733743 (1998-03-01), Johnson et al.
patent: 5738996 (1998-04-01), Hodges
patent: 5763192 (1998-06-01), Kauffman et al.
patent: 5763733 (1998-06-01), Whitlow et al.
patent: 5767260 (1998-06-01), Whitlow et al.
patent: 5780225 (1998-07-01), Wigler et al.
patent: 5789208 (1998-08-01), Sharon
patent: 5814476 (1998-09-01), Kauffman et al.
patent: 5817483 (1998-10-01), Kauffman et al.
patent: 5824483 (1998-10-01), Houston, Jr. et al.
patent: 5824514 (1998-10-01), Kauffman et al.
patent: 5837477 (1998-11-01), Germain et al.
patent: 5837500 (1998-11-01), Ladner et al.
patent: 5840304 (1998-11-01), Davis et al.
patent: 5858657 (1999-01-01), Winter et al.
patent: 5861156 (1999-01-01), George et al.
patent: 5866344 (1999-02-01), Georgiou
patent: 5866363 (1999-02-01), Pieczenik
patent: 5869620 (1999-02-01), Whitlow et al.
patent: 5871907 (1999-02-01), Winter et al.
patent: 5871974 (1999-02-01), Huse
patent: 5882945 (1999-03-01), Saito et al.
patent: 5900476 (1999-05-01), Ruggeri et al.
patent: 5948409 (1999-09-01), Germain et al.
patent: 5969108 (1999-10-01), McCafferty et al.
patent: 5977321 (1999-11-01), Saito et al.
patent: 6017732 (2000-01-01), Jespers et al.
patent: 6027910 (2000-02-01), Klis et al.
patent: 6057098 (2000-05-01), Buechler et al.
patent: 6087096 (2000-07-01), Dau et al.
patent: 6114147 (2000-09-01), Frenken et al.
patent: 6291158 (2001-09-01), Winter et al.
patent: 6291161 (2001-09-01), Lerner et al.
patent: 6300065 (2001-10-01), Kieke et al.
patent: 6319713 (2001-11-01), Patten et al.
patent: 6335163 (2002-01-01), Sharon
patent: 6406863 (2002-06-01), Zhu et al.
patent: 6410246 (2002-06-01), Zhu et al.
patent: 6410271 (2002-06-01), Zhu et al.
patent: 6416971 (2002-07-01), Reinherz et al.
patent: 6423538 (2002-07-01), Wittrup et al.
patent: 6610472 (2003-08-01), Zhu et al.
patent: 6653068 (2003-11-01), Frisch et al.
patent: 6696251 (2004-02-01), Wittrup et al.
patent: 6699658 (2004-03-01), Wittrup et al.
patent: 6794132 (2004-09-01), Buechler et al.
patent: 6986986 (2006-01-01), Buechler et al.
patent: 2002/0025536 (2002-02-01), Gyuris et al.
patent: 2002/0123057 (2002-09-01), Zauderer et al.
patent: 2003/0186374 (2003-10-01), Hufton et al.
patent: 2003/0232333 (2003-12-01), Ladner et al.
patent: 2003/0232395 (2003-12-01), Hufton
patent: 2003/0235864 (2003-12-01), Ashkar
patent: 2004/0029113 (2004-02-01), Ladner et al.
patent: 2004/0067532 (2004-04-01), Zhu et al.
patent: 2004/0146976 (2004-07-01), Wittrup et al.
patent: 2004/0171065 (2004-09-01), Kim et al.
patent: 2004/0180348 (2004-09-01), Pan et al.
patent: 2005/0003384 (2005-01-01), Huse
patent: 2005/0038232 (2005-02-01), Karrer et al.
patent: 2005/0063970 (2005-03-01), Reiter et al.
patent: 2005/0123996 (2005-06-01), Zhu et al.
patent: 2005/0142562 (2005-06-01), Zhu et al.
patent: 2005/0169937 (2005-08-01), Buist et al.
patent: 2005/0196755 (2005-09-01), Zauderer et al.
patent: 0 436 597 (1991-07-01), None
patent: 0673427 (1995-09-01), None
patent: 0682710 (1995-11-01), None
patent: 0934526 (2003-01-01), None
patent: 0779933 (2003-04-01), None
patent: WO94/01567 (1994-01-01), None
patent: WO94/18330 (1994-08-01), None
patent: 98 39482 (1998-09-01), None
patent: WO98/49286 (1998-11-01), None
patent: 99 36569 (1999-07-01), None
patent: WO 99/36569 (1999-07-01), None
patent: WO 01/48145 (2001-07-01), None
patent: WO 0179481 (2001-10-01), None
patent: WO 0200728 (2002-01-01), None
patent: WO 02055718 (2002-07-01), None
patent: WO 03029456 (2003-04-01), None
patent: 2004/074322 (2004-09-01), None
patent: 2006/016113 (2006-02-01), None
US 6,331,391, 12/2001, Wittrup et al. (withdrawn)
Al-Ramadi BK, et al., (1995)Lack of strict correlation of functional sensitation with the apparent affinity of MHC/peptide complexes for the TCR.J. Immunol. 155: 662-673.
Bellio M, et al., (1994), The Vβ complementarity determining region 1 of a major histocompatibility complex (MHC) class 1-restricted T cell receptor is involved in the recognition of peptide/MHC I and superantigen/MHC complex.J. Exp. Med. 179: 1087-1089.
Bird, RE, et al., (1988), Single-chain antigen-binding proteins.Science. 242: 423-426.
Boder, E.T., et al., (2000), Yeast surface display for directed evolution of protein expression, affinity, and stability.Methods Enzymol328, 430-444.
Brodnicki, TC., (1996), Reactivity and epitope mapping of single-chain T cell receptors with monoclonal antibodies.Mol. Immunol. 33:253-263.
Cho, BK, et al., (1995), Characterization of a single-chain antibody to the β-chain of the T cell receptor.J. Biol. Chem. 270: 25819-25826.
Cochran, et al., (2000), A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions. Chemistry & Biology, vol. 7:683-696.
Corr M, et al., (1994), T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity.Science265: 946-949.
Engel I, et al., (1988), Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition.Cell54: 473-484.
Holler, Phillip D., et al., (2001), CD8- T Cell Transfectants that Expre

Affiliated with

Also associated with

Rating

High affinity TCR proteins and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High affinity TCR proteins and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High affinity TCR proteins and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4066318