High affinity ssDNA ligands of HIV-1 reverse transcriptase

Details High affinity ssDNA ligands of HIV-1 reverse transcriptase High affinity ssDNA ligands of HIV-1 reverse transcriptase

1995-05-17

1998-07-28

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 921, 935 77, 935 78, C07H 2104, C12Q 168, C12P 1934

Patent

active

057864624

ABSTRACT:
Methods are described for the identification and preparation of DNA ligands to the HIV-1 reverse transcriptase protein. Included in the invention are specific ssDNA ligands to HIV-1 reverse transcriptase identified by the SELEX method. Also included are ssDNA ligands that inhibit HIV-1 reverse transcriptase.

REFERENCES:
patent: 4833092 (1989-05-01), Geysen
patent: 5133866 (1992-07-01), Kauvar
patent: 5270163 (1993-12-01), Gold et al.
patent: 5475096 (1995-12-01), Gold et al.
patent: 5496938 (1996-03-01), Gold et al.
Arnold et al. (1992) Nature 357:85.
Baltimore (1970) Nature 226:1209.
Carey et al. (1983) Biochemistry 22:2601.
Davies et al. (1991) Science 252:88.
Gilboa et al. (1979) Cell 18:93.
Huang et al. (1990) J. Biol. Chem. 265:11914.
Irvine et al. (1991) J. Mol. Biol. 222:739.
Jaeger et al. (1989) Proc. Natl. Acad. Sci. USA 86:7706.
Kedar et al. (1990) Biochemistry 29:3603.
Kohlstaedt et al. (1992) Science 256:1783.
Kopp et al. (1991) Nuc. Acids Res. 19(11):3035.
Krug and Berger (1991) Biochemistry 30:10614.
Lowary and Uhlenbeck (1987) Nucleic Acids Res. 15:10483.
Jocobo-Molina et al. (1993) Proc. Natl. Acad. Sci. USA 90:6320.
Marshall and Caruthers (1993) Science 259:1564.
Merluzzi et al. (1990) Science 250:1411.
Nakane and Ono (1990) Biochemistry 29:2841.
Pauwels et al. (1990) Nature 343:470.
Peliska and Benkovic (1992) Science 258:1112.
Schneider et al. (1993) FASEB 7:201.
Temin and Mizutani (1970) Nature 226:1211.
Tuerk and Gold (1990) Science 249:505.
Tuerk et al. (1992) Proc. Natl. Acad. Sci. USA 89:6988.
Yarus and Berg (1970) Anal. Biochem. 35:450.
Zuker (1989) Science 244:48.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Oliphant et al. (1989) Mol. Cell Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.

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