High affinity NY-ESO T cell receptors

Details High affinity NY-ESO T cell receptors High affinity NY-ESO T cell receptors

2011-08-30

2011-08-30

Juedes, Amy (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

08008438

ABSTRACT:
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC (SEQ ID NO:126)-HLA-A*0201, the SLLMWITQC (SEQ ID NO:126) peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KDfor the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3S−1or slower.

REFERENCES:
patent: WO 03/020763 (2003-03-01), None
Pardoll, 2002, Nat. Biotech. vol. 20: 1207-1208.
Morgan et al., 2006, Science, vol. 314: 126-129.
Jäger et al., “Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes,”J. Exp. Med. 187, 265-70, 1998.
Li et al., “Directed evolution of human T-cell receptors with picomolar affinities by phage display,”Nature Biotechnol. 23, 349-54, 2005.

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