Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-04-27
1997-08-26
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 221, 935 77, 935 78, C07H 2102, C07H 2104, C12P 1934, C12Q 168
Patent
active
056609850
ABSTRACT:
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2'- and 5-position. Specific 2-OH and 2'-NH.sub.2 modified RNA ligands to thrombin are described.
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Gold Larry
Janjic Nebojsa
Kirschenheuter Gary P.
Pieken Wolfgang
Tasset Diane
NeXstar Pharmaceuticals, Inc.
Zitomer Stephanie W.
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