Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-08-25
1999-09-28
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 2431, 536 245, 536 231, 536 221, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
059586915
ABSTRACT:
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2'- and 5-position. Specific 2-OH and 2'-NH.sub.2 modified RNA ligands to thrombin are described.
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Gold Larry
Janjic Nebojsa
Kirschenheuter Gary P.
Pieken Wolfgang
Tasset Diane
NeXstar Pharmaceuticals, Inc.
Zitomer Stephanie W.
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