Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1996-01-11
1998-09-08
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435243, 435325, 530324, C07K 14435, C12N 120, C12N 1585
Patent
active
058044450
ABSTRACT:
The present invention relates to inhibitors of the sequence specific transcription factor nuclear factor IL-6 (NF-IL6) and methods of use therefor. In particular, substitution mutants in the N-terminus of the NF-IL6 tryptic core domain are disclosed that have a higher binding affinity for the DNA binding site than does the wild-type sequence.
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Board of Regents , The University of Texas System
Nelson Amy J.
Robinson Douglas W.
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