High-affinity melatonin receptor and uses thereof

Details High-affinity melatonin receptor and uses thereof High-affinity melatonin receptor and uses thereof

2006-07-25

2006-07-25

Pak, Michael (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S069100

Reexamination Certificate

active

07081349

ABSTRACT:
Disclosed are cDNAs and DNAs encoding high-affinity melatonin 1a and 1b receptors and the recombinant polypeptides expressed from such cDNAs. The recombinant receptor polypeptides, receptor fragments and analogs expressed on the surface of cells are used in methods of screening candidate compounds for their ability to act as agonists or antagonists to the effects of interaction between melatonin and high-affinity melatonin receptor. Agonists are used as therapeutics to reentrain endogenous melatonin rhythms as a means of treating circadian rhythm disorders in humans and control reproductive cycles in seasonally breeding animals. Antagonists are used as therapeutics to control the initiation or timing of puberty in humans. Antibodies specific for a high-affinity melatonin receptor (or receptor fragment or analog) and their use as a therapeutic are also disclosed.

REFERENCES:
patent: 4880826 (1989-11-01), Zisapel et al.
patent: 5194614 (1993-03-01), Andrieux et al.
patent: 5240919 (1993-08-01), Yous et al.
patent: 5276051 (1994-01-01), Lesieur et al.
patent: 5464872 (1995-11-01), Langlois et al.
patent: 5508164 (1996-04-01), Kausch et al.
patent: 5554642 (1996-09-01), Langlois et al.
patent: 0591057 (1993-01-01), None
patent: 0591057 (1993-10-01), None
patent: 2 192 001 (1987-12-01), None
patent: PCT/US95/07360 (1995-06-01), None
patent: WO 95/35320 (1995-12-01), None
Anis et al, “Affinity Labeling of Melatonin Binding Sites In The Hamster Brain”,Biochemical and Biophysical Research Communications, 178 (3):1147-1152 (1991).
Morgan et al., “Melatonin Receptors: Localization, Molecular Pharmacology and Physiological Significance”,Neurochemistry International, 24 (2):101-146 (1994).
Stankov et al., “Melatonin Signal Transduction and Mechanism of Action in the Central Nervous System: Using the Rabbit Cortex as a Model”,Endocrinology, vol. 130:2152-2159.
Fraser et al., “Melantonin receptor mRNA expression in Xenopus oocytes: inhibition of G-protein-activated response”, Chemical Abstracts, vol. 115:65212b (1991).
G. Spandoni et al., “2-Substituted 5-Methoxy-N-acyltryptamines: Synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity”Journal of Medicinal Chemistry, vol. 36 (1993), 4069-4074.
S.M. Reppert et al., “Putative melatonin receptors in a human biological clock”Science, vol. 242 (1988), 78-81.
S.W. Ying et al., “Human malignant melanome cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin”European Journal of Pharmacology—Molecular Pharmacology Section, vol. 246 (1993), 89-96.
E. Duranti et al., “2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist”Life Sciences, vol. 51 (1992), 479-485.
S.P. Fraser et al., “Melatonin receptor mRNA expression inXenopusoocytes: inhibition of G-protein-activated response”Neuroscience Letters, 123 (1991), 242-245.
M.L. Dubocovich, “Pharmacology and function of melatonin receptors”The FASEB Journal, vol. 2 (1988), 2765-2773.
L.L. Carlson et al., Melatonin signal transduction in hamster brain: Inhibition of adenylyl cyclase by a pertussis toxin-sensitive G proteinEndocrinology, vol. 125 (1989), 2670-2676.
Yous et al., “Novel naphtlaenic ligands with high affinity for the melatonin receptor”Journal of Medicinal Chemistry, vol. 35 (1992), 1484-1486.
Bagnara, J.T. and Hadley, M.E., “Endocrinology of the Amphibian Pineal”,Am. Zoologist(1970) 10:201-216.
Bartness, T.J. and Goldman, B.D., “Mammalian pineal melatonin:A clock for all seasons”,Experienta(1989) 45:939 945.
Bittman, E. L. and Weaver, D. Dr., “The distribution of melatonin binding sites in neuroendocrine tisues of the ewe”,Biology of Reproduction, (1990) 43:986-993.
Carlson, L.L. et al., “Melatonin Signal Transduction in Hamster Brain:Inhibition of Adenylyl Cyclase by a Pertussin Toxin-Sensitive G Protein”,Endocrinology(1989) 125:2670-2676.
Dubocovich, M.L. and Takahashi, J.S. “Use of 2-[125I] iodomelatonin to characterize melatonin binding sites in chicken retina”Proc. Natl. Sci. USA(1987) 84:3916-3920.
Ebisawa, T. et al., “Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores”,Proc. Natl. Acad. Sci. USA, (1994) 92:6133-6137.
Geissler, E.M. et al., “Stem Cell Factor (SCF), a Novel Hematopoietic Growth Factor and Ligand for c-kit Tyrosine Kinase Receptor, Maps on Human Chromosome 12 between 12q14.3 and 12qter”,Somatic Cell and Molecular Genetics, (1991), 17(2):207-214.
Glaser, T., Housman, D., Lewis, W.H., Gerhard, D. & Jones C. “A Fine-Structure Deletion Map of Human Chromosome 11p: Analysis of J1 Series Hybrids”Somet.Cell. Mol. Genet, (1989) 15:477-501, Fig. 23.
Karne, S. et al., “Cloning and Characterizaton of an Endothelin-3 Specific Receptor (ETcReceptor) from Xenopus laevis Dermal Melanophores”,J. Biol. Chem.(1993) 268:19126-19133.
Karsch, F.J. et al., “Neuroendocrine Basis of Seasonal Reproduction”,Recent Prog. Norm. Res.(1984) 40:185-232.
Kozak, M., “An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs”,Nucleic Acids Res.(1987) 15:8125-8148.
Kyte, J. and Doolittle, R.F., “A Simple Method for Displaying the Hydropathic Character of a Protein”,J. Mol. Biol.(1982) 157:105-132.
Laitinen, J.T. and Saavedra, J.M., “Characterization of Melatonin Receptors in the Rat Suprachiasmatic Nuclei:Modulation of Affinity with Cations and Guanine Nucleotides”,Endocrinology(1990) 126:2110-2115.
Morgan, P.J. et al., “Guanine Nucleotides Regulate the Affinity of Melatonin Receptors on the Ovine Pars tuberalis”,Neuroendocrinology(1989) 50:359-362.
Munson, P.J. and Rodbard, D., “LIGAND:A Versatile Computerized Approach for Characterization of Ligand-Binding Systems”,Anal. Biochem.(1980) 107:220-239.
Pelletier, J. et al., “Short Communication—Assignment of Two of the Translation Initiation Factor-4E (EIF4EL1 and EIF4EL2) Genes to Human Chromosomes 4 and 20”,Genomics(1991) 10(4):1079-1082.
Reppert, S.M. et al., “Putative Melatonin Receptors in a Human Biological Clock”,Science(1988) 242:78-81.
Reppert, S.M et al., “Cloning and Characterization of a Mammalian Melatonin Receptor That Mediates Reproductive and Circadian Responses”,Neuron(1994) 13:1177-1185.
Rivkees, S.A. et al., “Guanine nucleotide-binding protein regulation of melatonin receptors in lizard brain”,Proc. Natl. Acad. Sci. USA(1989) 86:3882-3886.
Vanecek, J., “Melatonin Binding Sites”,J. Neurochem.(1988) 51:1436-1440.
Weaver, D.R. et al., “Localization of Melatonin Receptors in Mammalian Brain” in Suprachiasmatic nucleus:the mind's clock, Klein, D.C. Moore, R.Y., and Reppert, S.M. (1991) eds. New York: Oxford University Press, pp 289-308.
Weaver, D.R. et al., “Localization and Characterization of Melatonin Receptors in Rodent Brain in vitro Autoradiography”,The Journal of Neuroscience(1989) 9(7):2581-2590.
Carlson, Linda L. et al. “Melatonin Signal Transduction in Hamster in Hamster Brain: Inhibition of Adenylyl Cyclase by a Pertussis Toxin-Sensitive G. Protein”,Endocrinology(1989) vol. 125:2670-2676.
Dubocovich, Margarita L., “Pharmacology and Function of Melatonin Receptors” FASEB Journal (1988) vol. 2)2765-2773.
Kopin, Alan S. et al., “Expression Cloning and Characterization of the Canine Parietal Cell Gastrin Receptor”Proc. Nalt.Acad.Sci. USA(1992) vol. 89:3605-3609.
Masu, Yasuo et al., “cDNA Cloning of Bovine Sustance-K Receptor Through Oocyte Expression System”Nature(1987) vol. 329:836-838.
Duranti et al., “2-Bromomelatonin: Synthesis and Characterization Of A Potent Melatonin Agoinst”Life Sciences51: 479-485 (1992).

Affiliated with

Also associated with

Rating

High-affinity melatonin receptor and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High-affinity melatonin receptor and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High-affinity melatonin receptor and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3538365