High affinity ligands bind to clostridium difficile toxin A

Details High affinity ligands bind to clostridium difficile toxin A High affinity ligands bind to clostridium difficile toxin A

2011-03-29

2011-03-29

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S123000

Reexamination Certificate

active

07915235

ABSTRACT:
Glycans are identified which have high affinity forC. difficiletoxin A. They share one of two saccharide backbones and may have additional side chains. The backbones are galactose-β1-3 N-acetyl-D-glucosamine-β-1-3-galactose-β-1-4-N-acetyl-D-glucosamine and galactose-α-1-3-galactose-β-1-4-N-acetyl-D-glucosamine. The ligands may be used therapeutically, prophylactically, and diagnostically.

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