High affinity immunoglobulin E receptor-like protein

Details High affinity immunoglobulin E receptor-like protein High affinity immunoglobulin E receptor-like protein

1998-12-15

1999-11-02

Saunders, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530350, A61K 3816, C07K 14735

Patent

active

059770724

ABSTRACT:
The invention provides a human high affinity immunoglobulin E receptor-like protein (IGERB) and polynucleotides which identify and encode IGERB. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of IGERB.

REFERENCES:
patent: 5552312 (1996-09-01), Lim
patent: 5639660 (1997-06-01), Kinet
Reischl, I.G., et al., Characterization of Fc epsilon RI expressing human monocytic cell lines. The role of CD45 on signal transduction in primary monocytes and cell lines. Int. Arch Allerg. Immunol. 113:444-453, 1997.
Gagari, E., et al., "Differential Release of Mast Cell Interleukin-6 Via c-kit", Blood, 89:2654-2663 (1997).
Paolini, R., et al., "Phophorylation and desphosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement", Nature, 353:855-858 (1991).
Beaven, M.A., et al., "Downstream signals initiated in mast cells by Fc.epsilon.RI and other receptors", Curr.Opin.Immunol., 8:766-772 (1996).
Kinet, J.P., et al., "Isolation and characterization of cDNAs coding for the .beta. subunit of the high-affinity receptor for immunoglobulin E", Proc. Natl. Acad. Sci. USA, 85:6483-6487 (1988).
Adra, C.N., et al., "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the .beta. subunit of the high-affinity IgE receptor: Evidence for a family of proteins with four membrane-spanning regions", Proc. Natl. Acad. Sci. USA, 91:10178-10182 (1994).
Sandford, A.J., et al., "Localisation of atopy and .beta. subunit of high-affinity IgE receptor (Fc.epsilon.RI) on chromosome 11q", Lancet, 341:332-334 (1993).
Adra, C.N., et al., (GI 561639) GenBank Sequence Database (Accession L35848), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (Feb. 22, 1995).
Adra, C.N., et al., (GI 561638) GenBank Sequence Database (Accession L35848), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (Feb. 22, 1995).
Kinet, J.-P., et al., (GI 204117) GenBank Sequence Database (Accession M22923), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (Jun. 15, 1989).
Kinet, J.-P., et al., (GI 204116) GenBank Sequence Database (Accession M22923, J 03845), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (Jun. 15, 1989).
Hillier, L. et al. GenBank Accession No. R08355 (Apr. 5, 1995).
Hillier, L. et al. GenBank Accession No. R63659 (May 26, 1995).
Levenosn C. and Chang C., in: PCR Protocols: A Guide to Methods and Applications, Innis, et al., eds, Academic Press, San Diego, pp. 99-112 (1990).
Kawasaki ES, ibid. pp. 146-158 (1990).
Hillier, et al. "The WashU-Merck EST Project," Emest7 Database entry Hs1152201; Acc No. AA234138 (Mar. 6, 1997).
Hillier, et al. "The WashU-Merck EST Project 1997," Emest8 Database entry Hs1213902; Acc No. AA418443 (May 14, 1997).

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