Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2009-12-15
2011-11-22
Woodward, Cherie M (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hormone or other secreted growth regulatory factor,...
C530S387100, C530S387900
Reexamination Certificate
active
08062640
ABSTRACT:
An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
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Benjannet S., et al. (2006) “The Proprotein Convertase (PC) PCSK9 Is Inactivated by Furin and/or PC5/6A.” J. Biol. Chem. 281(41): 30561-30572.
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Chan, Joyce C.Y., et al. (2009) “A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduced serum cholesterol in mice and nonhuman primates.” PNAS. 106(24): 9820-9825.
Huang Tammy T
MacDonald Douglas
Martin Joel H.
Sleeman Mark W.
Cottingham Frank R.
Gregg Valeta
Regeneron Pharmaceuticals Inc.
Woodward Cherie M
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