High affinity human antibodies to human nerve growth factor

Details High affinity human antibodies to human nerve growth factor High affinity human antibodies to human nerve growth factor

2011-08-02

2011-08-02

Kemmerer, Elizabeth C (Department: 1649)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S142100, C530S388150, C530S388240

Reexamination Certificate

active

07988967

ABSTRACT:
A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KDof 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

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