Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2007-04-06
2009-11-10
Mertz, Prema (Department: 1646)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S141100, C530S388220
Reexamination Certificate
active
07615220
ABSTRACT:
An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
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Monoclonal Anti-human IL-18 Ra/IL-1 R5 Antibody (Clone 70625) Feb. 18, 2005 retrieved from the internet : URL:http://www.rndsystems.com/pdf/mab840.p.
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Xu, D et al. (1998) Selective expression and functions of interleukin 18 . . . Journal of Experimental Medicine 188(8):1485-1492.
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Fairhurst Jeanette L.
Huang Tammy H.
Karow Margaret
Martin Joel H.
Mikulka Warren R.
Gregg, Esq. Valeta
Mertz Prema
Regeneron Pharmaceuticals Inc.
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