High affinity human antibodies to human IL-18 receptor

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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C424S141100, C530S388220

Reexamination Certificate

active

08003103

ABSTRACT:
An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.

REFERENCES:
patent: 6600022 (2003-07-01), Torigoe et al.
patent: 2008/0063644 (2008-03-01), Sekiyama
patent: WO 2006/009114 (2006-01-01), None
Nishida, Y E et al. (1998) Cloning and expression of a single-chain Fv fragment. Hybridoma 17(6):577-580.
Monoclonal Anti-Human IL-18 Ra/IL-1 R5 Antibody (Clone 70625) Feb. 18, 2005 retrieved from the internet:URL:http://www.mdsystems.com/pdf/mab840.p.
Vermot-Desroches, C et al. (2005) Monoclonal antibodies specific for the IL-18 receptor Cellular Immunology 236(1-2):101-104.
Xu, D et al. (1998) Selective expression and functions of interleukin 18. Journal of Experimental Medicine 188(8):1485-1492.
Kitasato, Y et al. (2004) Enhanced expression of interleukin-18 and its receptor in idiopathic . . . American Journal of Respiratory Cell and Molecular Biiology 31(6):619-625.

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