High affinity HKGF nucleic acid ligands and inhibitors

Details High affinity HKGF nucleic acid ligands and inhibitors High affinity HKGF nucleic acid ligands and inhibitors

1995-06-05

1998-12-08

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 254, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C07H 2102

Patent

active

058467130

ABSTRACT:
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to hKGF. Included in the invention are specific RNA ligands to hKGF identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of hKGF with its receptor.

REFERENCES:
patent: 5459015 (1995-10-01), Janjic et al.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract of paper presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman (1968) Proc. Natl. Acad. Sci. USA 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Olliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.
Alarid et al. (1994) Proc. Natl. Acad. Sci. USA 91:1074.
Bottaro et al. (1993) J. Biol. Chem. 268:9180.
R&D Systems, Specification Sheet For Anti-Human FGF-7/KGF Neutralizing Antibody, dated Feb. 1, 1995.

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