High affinity HIV integrase inhibitors

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 912, 935 77, 935 78, 536 254, C12P 1934, C12Q 168, C07H 2102, C07H 2104

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active

057562873

ABSTRACT:
Methods are described for the identification and preparation of nucleic acid ligands to HIV integrase. Included in the invention are specific RNA ligands to HIV integrase identified by the SELEX method. Also included in the invention are specific RNA ligands that are inhibitors of HIV integrase.

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