High affinity HIV integrase inhibitors

Details High affinity HIV integrase inhibitors High affinity HIV integrase inhibitors

1994-12-21

1998-05-26

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 935 77, 935 78, 536 254, C12P 1934, C12Q 168, C07H 2102, C07H 2104

Patent

active

057562873

ABSTRACT:
Methods are described for the identification and preparation of nucleic acid ligands to HIV integrase. Included in the invention are specific RNA ligands to HIV integrase identified by the SELEX method. Also included in the invention are specific RNA ligands that are inhibitors of HIV integrase.

REFERENCES:
patent: 5428149 (1995-06-01), Eaton
patent: 5459015 (1995-10-01), Janjic et al.
patent: 5472841 (1995-12-01), Jayasena et al.
patent: 5476766 (1995-12-01), Gold et al.
patent: 5496938 (1996-03-01), Gold et al.
patent: 5503978 (1996-04-01), Schneider et al.
patent: 5527894 (1996-06-01), Gold et al.
patent: 5543293 (1996-08-01), Gold et al.
patent: 5567588 (1996-10-01), Gold et al.
Joyce (1989) Gene 82:83.
Joyce and Inoue (1989) Nucleic Acids Research 17:711.
Ellington and Szostak (1990) Abstract of papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 226.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645.
Kramer et al. (1974) J. Mol. Biol. 89:719.
Levisohn and Spiegelman (1969) Proc. Natl. Acad. Sci. USA 63:805.
Levisohn and Spiegelman Proc. Natl. Acad. Sci. USA 60:866.
Oliphant et al. (1989) Mol. Cell. Biol. 9:2944.
Oliphant and Struhl (1988) Nucleic Acids Research 16:7673.
Oliphant and Struhl (1987) Methods in Enzymology 155:568.
Oliphant et al. (1986) Gene 44:177.
Robertson and Joyce (1990) Nature 344:467.
Thiesen and Bach (1990) Nucleic Acids Research 18:3203.

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