High-affinity choline transporter

Details High-affinity choline transporter High-affinity choline transporter

2007-11-13

2007-11-13

Andres, Janet L. (Department: 1649)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S007210, C435S069100, C435S252300, C435S320100, C436S501000, C530S350000

Reexamination Certificate

active

11601793

ABSTRACT:
The present invention provides a protein having high-affinity choline transporter activity which is important physiologically, a gene encoding the protein, and a method of screening a material promoting the high-affinity choline transporter activity with the use of the same, and the like. By examining high-affinity choline uptake activity of Na+-dependent transporter cDNA deduced from the genomic sequence of a nematode (C. elegans) in a Xenopus oocyte expression system, the cDNA (cho-1) of nematode high-affinity choline transporter is identified. Then the cDNA (CHT1) of rat high-affinity choline transporter is cloned from rat spinal cord by using the homology of a base sequence to this cDNA as an index. Similarly, the cDNA of human high-affinity choline transporter is cloned from human genome.

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