High-affinity antagonists of ELR-CXC chemokines

Details High-affinity antagonists of ELR-CXC chemokines High-affinity antagonists of ELR-CXC chemokines

2008-07-14

2010-06-22

Mertz, Prema (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

Reexamination Certificate

active

07741434

ABSTRACT:
The present invention provides novel polypeptide sequences, methods for production thereof and uses thereof for novel ELR-CXC chemokine receptor agonists and antagonists.

REFERENCES:
patent: 5665346 (1997-09-01), Clark-Lewis et al.
Clark-Lewis I et al: “Structural Requirements for Interleukin-8 Function Identified by Design of Analogs and CXC Chemokine Hybrids” Journal of Biological Chemistry, American Society of Biological Chemists, Baltimore, MD, US, vol. 269, No. 23.
Clark-Lewis I et al: “Structure-Activity Relationships of Chemokines” Journal of Leukocyte Biology, Federation of American Socieities for Experimental, US, vol. 57, No. 5, May 1, 1995, pp. 703-711, XP000569546 ISSN: 0741-5400 cited in the application the whole document.
Hayashi S et al: “Synthetic Hexa-and Heptapeptides That Inhibit IL-8 From Binding to and Activating Human Blood Neutrophils” Journal of Immunology, The Williams and Wilkins Co. Baltimore, US, vol. 154, 1995, pp. 814-824, XP002913718 ISSN: 0022-1767.

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