Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2010-01-11
2010-06-22
Saidha, Tekchand (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S196000, C435S197000
Reexamination Certificate
active
07740840
ABSTRACT:
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
REFERENCES:
patent: 7438904 (2008-10-01), Zhan et al.
Yang Wenchao
Zhan Chang-Guo
Zheng Fang
Decker Mandy Wilson
Saidha Tekchand
Stites & Harbison PLLC
University of Kentucky Research Foundation
LandOfFree
High activity mutants of butyrylcholinesterase for cocaine... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with High activity mutants of butyrylcholinesterase for cocaine..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High activity mutants of butyrylcholinesterase for cocaine... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4150384