HIF inhibitors

Details HIF inhibitors HIF inhibitors

2006-08-25

2011-12-06

Andres, Janet L. (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08071795

ABSTRACT:
HIF-1 inhibitors and methods of use thereof are provided.

REFERENCES:
patent: 2004/087066 (2004-10-01), None
patent: 2004/087066 (2004-10-01), None
International Search Report and Written Opinion, dated Jul. 29, 2008.
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Pugh, C., et al., 2001, “Hypoxia and oxidative stress in breast cancer. Hypoxia signalling pathways;” Breast Cancer Res., 3(5), pp. 313-317.
Semenza, Gregg, 2002, entitled “Involvement of hypoxia-inducible factor 1 in human cancer” first sentence of col. 2, p. 80, Intern Med., 41(2), pp. 79-83.
Zhong, H., et al., 1999, “Overexpression of hypoxia-inducible factor lalpha in common human cancers and their metastase”, Cancer Res., 59(22), p. 5830.
Zhong, H., et al., 2001, “Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells”, Biochem Biophys Res Commun., 284(2), pp. 352-356.
Narita et al., “Identification of a Novel Small Molecule HIF-1α Translation Inhibitor,” Clinical Cancer Research, 15(19): 6128-6136 (2009).
Nicolaou et al., “Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistantStaphylococcus aureus(MRSA),” Chemistry—A European Journal, 7(19): 4280-4295 (2001).
Tan et al., “Identification of a Novel Small-Molecule Inhibitor of the Hypoxia-Inducible Factor 1 Pathway,” Cancer Research, 65(2):605-612 (2005).

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