HGI-Glycoprotein capable of stimulating proliferation and differ

Details HGI-Glycoprotein capable of stimulating proliferation and differ HGI-Glycoprotein capable of stimulating proliferation and differ

1979-03-19

1981-06-23

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

260112R, 424101, 424177, A61K 3522, C07G 700

Patent

active

042750563

ABSTRACT:
A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinitive chromatography with sugar affinitire adsorbents and electrophoresis.

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Kellar et al., Proc. of the Soc. for Exp. Biology and Medicine, 150, pp. 766-772 (1975).
Bourrillon, Proteins in Normal and Pathological Urine, pp. 20-44, Karger, Basel/New York (1970).
Chem. Abstracts, vol. 55, 1961, 716g-717a, Bourillon et al.
Kellar et al., Fed. Proceed., vol. 33, No. 4, 681 (1974).
Kellar et al., Chem. Absts., vol. 84: 71,099j (1976).
Wieslander et al., Clin. Chim. Acta, 78(3), pp. 391-400 (1977).
Carrea et al., Bichim. Biophys. Acta, 295(1), pp. 274-282 (1973).

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