HGF precursor protein variant and active protein thereof

Details HGF precursor protein variant and active protein thereof HGF precursor protein variant and active protein thereof

2011-08-23

2011-08-23

Allen, Marianne P (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S069100, C435S070100, C435S320100, C435S325000, C530S350000, C530S399000, C530S402000, C530S407000

Reexamination Certificate

active

08003607

ABSTRACT:
An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.

REFERENCES:
patent: 5879910 (1999-03-01), Godowski et al.
patent: 7098002 (2006-08-01), Rubinstein et al.
patent: 7220569 (2007-05-01), Himmelspach et al.
patent: 7351540 (2008-04-01), Carr
patent: 2003/0124653 (2003-07-01), Canfield
patent: 2004/0138120 (2004-07-01), Kirchhofer et al.
T. Nakamura, “Kansaibo Zoshoku Inshi (HGF) no Bunshi Cloning”, Experimental Medicine, 1990, vol. 8, No. 3, pp. 250-255 with an English translation thereof.
S. M. Hunt et al.,“Processing of mutated human proinsulin to mature insulin in the non-endocrine cell line, CHO”, Cytotechnology, vol. 21, No. 3, pp. 279-288, 1996.
Peek, Mark et al., “Unusual Proteolytic Activation of Pro-hepatocyte Growth Factor by Plasma Kallikrein and Coagulation Factor Xla,” Journal of Biological Chemistry, vol. 277, No. 49, Dec. 6, 2002, pp. 47804-47809.

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