HGF beta chain variants

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07737115

ABSTRACT:
The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.

REFERENCES:
patent: 4342566 (1982-08-01), Theofilopoulos et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5227158 (1993-07-01), Jardieu
patent: 5316921 (1994-05-01), Godowski et al.
patent: 5328837 (1994-07-01), Godowski et al.
patent: 5362716 (1994-11-01), Kmiecik et al.
patent: 5547856 (1996-08-01), Godowski et al.
patent: 5871959 (1999-02-01), Rong et al.
patent: 5879910 (1999-03-01), Godowski et al.
patent: 6207152 (2001-03-01), Schwall et al.
patent: 6214344 (2001-04-01), Schwall et al.
patent: 6468529 (2002-10-01), Schwall et al.
patent: 0 567 585 (1993-11-01), None
patent: WO 92/05184 (1992-04-01), None
patent: WO 92/13097 (1992-08-01), None
patent: WO 92/20792 (1992-11-01), None
patent: WO 93/15754 (1993-08-01), None
patent: WO 93/23541 (1993-11-01), None
patent: WO 93/23550 (1993-11-01), None
patent: WO 94/04679 (1994-03-01), None
patent: WO 94/06909 (1994-03-01), None
patent: WO 94/29348 (1994-12-01), None
patent: WO 95/01376 (1995-01-01), None
patent: WO 98/19696 (1998-05-01), None
patent: 2005/001486 (2005-01-01), None
Angeloni et al., “The Soluble Sema Domain of the RON Receptor Inhibits Macrophage-stimulating Protein-induced Receptor Activation”Journal of Biological Chemistry279(5):3726-3732 (Jan. 2004).
Asami et al., “Purification and Characterization of Hepatocyte Growth Factor from Injured Liver of Carbon Tetrachloride-Treated Rats”J Biochem(Tokyo) 109(1):8-13 (Jan. 1991).
Bellusci et al., “Creation of an Hepatocyte Growth Factor/Scatter Factor Autocrine Loop in Carcinoma Cells Induces Invasive Properties Associated with Increased Tumorigenicity”Oncogene9(4):1091-1099 (Apr. 1994).
Birchmeier et al., “Met, Metastasis, Motility and More”Nature Reviews Molecular Cell Biology4:915-925 (Dec. 2003).
Boerner et al., “Production of Antigen-Specific Human Monoclonal Antibodies From In Vitro-Primed Human Splenocytes”The Journal of Immunology147(1):86-95 (Jul. 1991).
Boose et al., “The Single-Chain Form of Tissue-Type Plasminogen Activator Has Catalytic Activity: Studies with a Mutant Enzyme That Lacks the Cleavage Site”Biochemistry28(2):635-643 (Jan. 24, 1989).
Bottaro et al., “Identification of the Hepatocyte Growth Factor Receptor as the c-met Proto-Oncogene Product”Science251:802-804 (Feb. 15, 1991).
Brodeur et al., “Mouse-Human Myeloma Partners for the Production of Heterohybridomas”Monoclonal Antibody Production Techniques and Applications, New York:Marcel Dekker, Inc. pp. 51-63 (1987).
Broze Jr. et al., “Protein Z-Dependent Regulation of Coagulation”Thromb. Haemost. 86(1):8-13 (Jul. 2001).
Bruggemann et al., “Designer Mice: The Production of Human Antibody Repertoires in Transgenic Animals”Year in Immunology7:33-40 (1993).
Carter et al., “Humanization of an Anti-p185HER2Antibody For Human Cancer Therapy”Proc. Natl. Acad. Sci. USA89(10):4285-4289 (May 1992).
Chamow et al., “A Humanized, Bispecific Immunoadhesin-Antibody That Retargets CD3+Effectors to Kill HIV-1-Infected Cells”Journal of Immunology153(9):4268-4280 (Nov. 1, 1994).
Chan et al., “Identification of a Competitive HGF Antagonist Encoded by an Alternative Transcript”Science254(5036):1382-1385 (Nov. 29, 1991).
Chan et al., “Isoforms of Human HGF and Their Biological Activities”Hepatocyte Growth Factor-Scatter Factor(HGF-SF)and the C-Met Receptor, I.D. Goldberg and E.M. Rosen eds., Basel: Birkhauser Verlag pp. 67-79 (1993).
Chirgadze et al., “Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implication for receptor activation”FEBS Letters430:126-129 (1998).
Chothia and Lesk, “Canonical Structures for the Hypervariable Regions of Immunoglobulins”J Mol Biol. 196(4):901-917 (Aug. 20, 1987).
Chothia et al., “Domain Association in Immunoglobulin Molecules. The Packing of Variable Domains”Journal of Molecular Biology186(3):651-663 (Dec. 5, 1985).
Cohen, G., “ALIGN: a program to superimpose protein coordinates, accounting for insertions and deletions”J Appl. Crystallog. 30:1160-1161 (1997).
Cole et al., “The EBV-Hybridoma Technique and Its Application to Human Lung Cancer”Monoclonal Antibodies and Cancer Therapy, New York:Alan R. Liss, Inc. pp. 77-96 (1985).
Collaborative Computational Project, No. 4, “The CCP4 suite: programs for protein crystallography.”Acta Crystallogr D Biol Crystallogr. 50(Pt 5):760-763 (Sep. 1, 1994).
Comoglio et al., “The Met/HGF-SF Receptor”Positive Growth Control(Abstract Only) 192:H215.
Comoglio, “Structure, Biosynthesis and Biochemical Properties of the HGF Receptor in Normal and Malignant Cells”Hepatocyte Growth Factor-Scatter Factor(HGF/SF)and the C-Met Receptor, I.D. Goldberg and E.M. Rosen eds., Basel:Birkhauser Verlag pp. 131-165 (1993).
Comoglio, “The HGF Receptor and Its Ligand: Structure, Signal Transduction and Biology”Cell Biology International(abstract only) 18(5):375 (1994).
Cooper et al., “Amplification and Overexpression of the MET Gene in Spontaneously Transformed NIH3T3 Mouse Fibroblasts”EMBO Journal5(10):2623-2628 (Oct. 1986).
Cooper et al., “Characterization of Human Transforming Genes from Chemically Transformed, Teratocarcinoma, and Pancreatic Carcinoma Cell Lines”Cancer Research44 (1):1-10 (Jan. 1984).
Cooper et al., “Molecular cloning of a new transforming gene from a chemically transformed human cell line”Nature311(5981):29-33 (Sep. 6, 1984).
Crepaldi et al., “Targeting of the SF/HGF Receptor to the Basolateral Domain of Polarized Epithelial Cells”J Cell Biol. (J Cell Biol. Apr. 1994;125(2):313-20) 125(2):313-320 (Apr. 1994).
Danilkovitch et al., “Interaction of macrophage-stimulating protein with its receptor. Residues critical for beta chain binding and evidence for independent alpha chain binding”J Biol Chem. 274(42):29937-29943 (Oct. 15, 1999).
Danilkovitch-Miagkova & Zbar, “Dysregulation of Met receptor tyrosine kinase activity in invasive tumors”The Journal of Clinical Investigation109(7):863-867 (Apr. 2002).
Date et al., “HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor”FEBS Letters420(1):1-6 (Dec. 22, 1997).
David and Reisfeld, “Protein Iodination with Solid State Lactoperoxidase”Biochemistry13(5):1014-1021 (Feb. 26, 1974).
de Sauvage et al., “Stimulation of Megakaryocytopoiesis and Thrombopoiesis by the c-Mpl Ligand”Nature369(6481):533-538 (Jun. 16, 1994).
Defrances et al., “The Presence of Hepatocyte Growth Factor in the Developing Rat”Development116(2):387-395 (Oct. 1992).
Dennis et al., “Peptide Exosite Inhibitors of Factor VIIa as Anticoagulants”Nature404(6777):465-470 (Mar. 30, 2000).
Derksen et al., “Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma”Blood99(4):1405-1410 (2002).
Di Cera et al., “The Na+ binding site of Thrombin”Journal of Biological Chemistry270(38):22089-22092.
Di Renzo et al., “Overexpression of the c-MET/HGF Receptor Gene in Human Thyroid Carcinomas”Oncogene7(12):2549-2553 (Dec. 1992).
Di Renzo et al., “Selective Expression of the Met/HGF Receptor in Human Central Nervous System Microglia”Oncogene8:219-222 (1993).
Dickinson et al., “Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa”Proc. Natl. Acad. Sci USA93(25):14379-14384 (Dec. 10, 1996).
Donate et al., “Molecular evolution and domain structure of plasminogen-re

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