Hexosylceramides as adjuvants and their uses in...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S023000, C536S017900, C536S004100

Reexamination Certificate

active

08053417

ABSTRACT:
The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumours, allergies as well as for the control of fertility in human or animal populations. The compounds are particularly useful not only as systemic, but preferably as mucosal adjuvants. In addition, the invention relates to its uses as active ingredients in pharmaceutical compositions.

REFERENCES:
patent: 0510356 (1992-03-01), None
patent: WO 99/52549 (1999-10-01), None
patent: WO 03009812 (2003-02-01), None
patent: WO 2004/009125 (2003-07-01), None
patent: WO 2004 028475 (2004-04-01), None
patent: WO 2006/027685 (2005-09-01), None
Vajdy et al. Mucosal Adjuvants and Delivery System for Protein, DNA, and RNA-based Vaccines, Immunology and cell Biology (2004) 82, pp. 617-627.
Singh et al. Advances in Vaccine Adjuvants, 1999 Nature Amarica Inc., pp. 1077-1081.

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