HEXIM1 as a suppressor of HIV replication and cardiac...

Details HEXIM1 as a suppressor of HIV replication and cardiac... HEXIM1 as a suppressor of HIV replication and cardiac...

2006-11-07

2006-11-07

Wang, Shengjun (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

C514S340000

Reexamination Certificate

active

07132454

ABSTRACT:
Cellular transcription is modulated by increasing or decreasing the amount of active HEXIM1 in the cell. The methods are applied to the treatment of HIV infection and cardiac hypertrophy. Assays using reconstituted 7SK:P-TEFb snRNP screen for agents that modulate HEXIM1-P-TEFb binding.

REFERENCES:
patent: 2003/0235588 (2003-12-01), Richon et al.
Yik et al. “Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the Coordinated actions of HEXIM 1 and 7SK snRNA,” Molecular Cells, Oct. 2003, vol. 12, pp. 971-982.
Michels et al. “MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in A transcription-dependent Manner,” Molecular and Cell Biology, Jul. 2003, vol. 23, No. 14, pp. 4859-4869.
Ouchida et al. “Suppression of NF-kB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM 1 inhuman vascular smooth muscle cell,” Genes to Cell, Aug. 2003, pp. 95-107.
Butler et al., Inhibition of Transformed Cell Growth and Induction of Cellular Differentiation by Pyroxamide . . . , Clin Cancer Res. 2001, 7:962-970.
Richon et al., A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases, Proc Natl Acad Sci U S A. (1998) 95:3003-3007.
Richon et al., Second generation hybrid polar compounds are potent inducers of transformed cell differentiation, Proc Natl Acad Sci U S A. (1996) 93:5705-5708.
Wang et al., New designed HMBA agents as Inducers of erythroleukemia cell differentiation, Chin Med Sci J. (2002) 17:27-31 (abstact only).

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