Hexapeptides deriving from aglucoteicoplanin and a process for p

Details Hexapeptides deriving from aglucoteicoplanin and a process for p Hexapeptides deriving from aglucoteicoplanin and a process for p

1994-06-23

1995-08-01

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C07K 900, A61K 3800

Patent

active

054381177

ABSTRACT:
Hexapeptides of formula (I) deriving from aglucoteicoplanin and their salts with acids and bases as well as their inner salts wherein R is hydrogen or a protecting ##STR1## group of the amino function. The products of formula (I), wherein R is hydrogen, possess antimicrobial activity in particular against coagulase-negative strains and some S. aureus and S. epidermidis strains which have low sensitivity toward teicoplanin. The hexapeptides are produced by reductive cleavage of aglucoteicoplanin with alkali metal borohydrides in the presence of a hydroalcoholic mixture as solvent.

REFERENCES:
Journal of the American Chemical Society, Perkin Transactions, vol. I, No. 12, 1 Dec. 1989, Letchworth GB pp. 2335-2339.

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