Hexameric complexes and their preparation

Details Hexameric complexes and their preparation Hexameric complexes and their preparation

2006-03-21

2006-03-21

Hartley, Michael (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C568S719000, C977S726000

Reexamination Certificate

active

07014868

ABSTRACT:
A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host assembly. A guest component, specifically a pharmaceutically active agent, is encapsulated within the spheroidal host assembly to provide a guest/host assembly exhibiting a high stability, being stable upon a solubilization in a mixture of acetone and water in a one-to-one ratio for a period of one day at a temperature of 37° C. The pharmaceutically active agent encapsulated within the spheroidal hexamer is selected from the group consisting of Depakote, Wellbutrin, Allegra, Neurontin, Zovirax, and Claritin. A process for the preparation of a hexameric complex, as described above, from a methylene-bridged tetramer solubilized in an amphiphilic organic solvent. An activator is incorporated into the amphiphilic solvent containing the tetramer. The activator comprises an organic compound of a lower molecular weight than that of the tetramer which is functionalized with at least one of an acidic group, a halogen, an amino group, an amido group, an ester group, or an hydroxy group. The tetramer may be prepared from an aldehyde and pyrogallol which are reacted under conditions to produce a condensation product of the methylene-bridged cyclic tetramer.

REFERENCES:
patent: 10245353 (1998-09-01), None
Gerkensmeier, et al., “Self-Assembly of 2,8,14,20-Tetraisobutyl-5,11,17,23-tetrahydroxyresore[4]arene,” Eur. J. Org. Chem., pp. 2257-2262, (Jan. 11, 1999).
MacGillivray, Leonard R. et al, ““ A chiral spherical molecular assembly held together by 60 hydrogen bonds”, ” Nature, p. 469-472, (Oct. 2, 1997).

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