Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressa

Details Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressa Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressa

1984-05-18

1986-06-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 71, 546 94, 514294, A61K 3147, C07D22118, C07D22122, C07D45100

Patent

active

045956880

ABSTRACT:
Novel compounds are disclosed, which are derivatives of 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]-isoquinolines, represented by general formula (I): ##STR1## as well as pharmaceutical compositions and methods for the treatment of depression in warm-blooded animals, e.g., man. Novel intermediates are also part of the invention.

REFERENCES:
patent: 3383388 (1968-05-01), Houlihan et al.
patent: 3502679 (1970-03-01), Houlihan et al.
patent: 3635984 (1972-01-01), Houlihan et al.
patent: 3892752 (1975-07-01), Houlihan et al.
"Use of the Butaclamol Template in a Search for Antipsychotic Agents with Lessened Side Effects", by Michael J. Kukla et al., in the Journal of Medicinal Chemistry, (1979) vol. 22 pp. 401-406.
Ronald C. Griffith et al., Journal of Medicinal Chemistry, vol. 27 pp. 995-1003 (Aug., 1984).
Abstract of European Pat. No. 107,825-A.
"Synthesis and Pharmacological Evaluation of Some Pyrrolo[2,1-a]Isoquinolines" Cesare Casagrande et al., Jul. 1968, pp. 765-770, vol. 11.
"Intramolecular Amidoalkylations at Carbon. Synthesis of Heterocyclic Amines", M. Winn et al., vol. 33, No. 10, Oct. 1968, pp. 3779-3783.

Affiliated with

Also associated with

Rating

Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressa does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressa will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2273409