Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-10-09
2007-10-09
Habte, Kahsay (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252010, C544S224000, C544S238000
Reexamination Certificate
active
11009249
ABSTRACT:
The present invention discloses and claims hexahydropyridazine-3-carboxylic acid hydrazides and hydrazones of formula (I)as inhibitors of proteases and kinases, and methods of using said compounds of formula (I) for the prevention or treatment of certain cardiovascular, central nervous system, inflammatory, and bone diseases as well as infectious diseases and certain cancers. Combinatorial libraries of the compounds of formula (I), pharmaceutical compositions, and methods for the preparation of combinatorial libraries and the compounds of formula (I) are also disclosed and claimed.
REFERENCES:
Cecil Textbook of Medicine (20th Edition, vol. 2, 1996, pp. 1736-1747.
Hale, K. J., Synthetic Route to the GE3 Cyclodepsipeptide, Organic Letters, vol. 4, No. 11, 2002, pp. 1903-1906.
Hale, K. J. , Asymetric Total Synthesis of Antitumor Antibiotic A83586C, Chemical Communications, vol. 23, 1997, pp. 2319-2320.
Leung, D. et al, Protease Inhibitors: Current Status and Future Prospects, Journal of Medicinal Chemistry, vol. 43, No. 3; Feb. 2000, pp. 305-341.
Bhatnagar Neerja
Broto Pierre
Gourvest Jean-Francois
Mauger Jacques
Aventis Pharma S.A.
Gupta Balaram
Habte Kahsay
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