Hexahydronaphthalene ester derivatives their preparation and the

Details Hexahydronaphthalene ester derivatives their preparation and the Hexahydronaphthalene ester derivatives their preparation and the

1995-12-28

1998-10-27

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

560119, 560127, 549292, 514460, 514547, 514292, 562467, C07D30930, C07C 6774, A01N 4342

Patent

active

058278559

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (II) or (III): ##STR2## R.sup.2 is alkyl, alkenyl or alkynyl; R.sup.3 and R.sup.4 are each hydrogen, alkyl, alkenyl or alkynyl; R.sup.5 is hydrogen or a carboxy-protecting group; R.sup.a is a group of formula --OR.sup.6 ; R.sup.6 is hydrogen; R.sup.6a and R.sup.6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.

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Patent Abstracts of Japan, unexamined applications, C section, vol. 9, No. 32, The Patent Office Japanese Government, p. 4 C 265, 1985, of JP 59-175450.
The Journal of Organic Chemistry, vol. 51, 1986, Issues 9-14, G.E. Keck et al, "A Highly Covergent Total Synthesis, of (+)-Compactin", p. 2487-2493.
Pike and Brown, Nutrition, pp. 531-535 (1984).

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