Hexahydronaphth[1,2-b]-1,4-oxazines

Details Hexahydronaphth[1,2-b]-1,4-oxazines Hexahydronaphth[1,2-b]-1,4-oxazines

1982-08-30

1983-12-13

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424857, 42424858, 544 99, 544101, A61K 31335, C07D49800

Patent

active

044204809

ABSTRACT:
Hexahydronaphth[1,2-b]-1,4-oxazines have dopaminergic activity and display .alpha..sub.2 -adrenergic receptor antagonism. They are useful in the treatment of parkinsonism, depression and hypertension. An important method of preparation is by ring closure of the appropriate 2-chloroacetamidotetrahydronaphthalen-1-ol and reduction of the resulting cyclic amide carbonyl group.

REFERENCES:
patent: 4238486 (1980-12-01), Jones
Neuman et al., J. Org. Chem., 28, 116 (1963).
Chem. Abstr., 85:177339y, Dalev et al.
Craig et al., J. Org. Chem., 39, 1669 (1974).

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