Hexahydrolupulones useful as anticancer agents

Details Hexahydrolupulones useful as anticancer agents Hexahydrolupulones useful as anticancer agents

1996-09-20

1998-10-27

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

424405, A61K 3112

Patent

active

058278958

ABSTRACT:
The present invention provides pharmaceutical compositions comprising an amount of hydrogenated lupulones or derivatives or analogs thereof, effective to inhibit cancer cell and/or bacterial cell growth, and methods of use thereof.

REFERENCES:
patent: 4140122 (1979-02-01), Kuhl et al.
patent: 4383529 (1983-05-01), Webster
patent: 4450270 (1984-05-01), Lunn
patent: 4590296 (1986-05-01), Cowles et al.
patent: 4668504 (1987-05-01), Kahan et al.
patent: 4783453 (1988-11-01), Christensen
patent: 4918240 (1990-04-01), Todd, Jr. et al.
patent: 4921857 (1990-05-01), Heck
patent: 4931279 (1990-06-01), Bawa et al.
patent: 5082975 (1992-01-01), Todd, Jr. et al.
patent: 5262151 (1993-11-01), Montgomery
patent: 5286506 (1994-02-01), Millis et al.
patent: 5370863 (1994-12-01), Barney
patent: 5455038 (1995-10-01), Barney
J. F. Carson, "The Hydrogenatio ofLupulone and Humulone", J. Amer. Chem. Soc., 73, 1850-1852, (1951).
Gilbert J. Mannering, et al., "Effects of the Hop Component, Colupulone, on the Induction of Cytochrome P4503A and the Replication of Human Tumour Cells", Food, Nutrition and Chemical Toxicity, Parke et al., eds., Smith Gordon G.B., Chapter 28, 311-323, (1993).
Ken Yasukawa, et al., "Humulon, a Bitter in the Hop, Inhibits Tumor Promotion by 12-0-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin", Oncology, 52, 156-158, (1995).
Mizobuchi, S., et al., "Antifungal Activities of Hop Bitter Resins and Related Compounds", Res. Lab. Kirin Brew. Co., No. 28, pp. 39-44, (1985).

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