Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-09-17
1986-01-28
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
2602444, 514299, 514212, C07D48700, A61K 31435
Patent
active
045672709
ABSTRACT:
This invention relates to hexahydroindolizinones, which are useful as inhibitors of cardiac arrhythmias and of platelet aggregation and are therefore useful in the treatment of irregular heartbeat and in the prevention of thrombus formation.
REFERENCES:
patent: 3274202 (1966-09-01), Mohrbacher
L. S. Goodman and A. Gilman, eds., The Pharmacological Basis of Therapeutics (New York, 1980), Sixth Edition, pp. 730-731, 750-751, 761-791, 1360-1361.
P. K. Yonan, "Synthesis and Antiarrhythmic Activity of .alpha.,.alpha.-Bis[(dialkylamino)-alkyl]phenyl acetamides," J. Med. Chem., 23, 1102-1108 (1980).
Chorvat Robert J.
Prodan Kathleen A.
Schulz John A.
Daus Donald G.
G. D. Searle & Co.
Henderson Richard E. L.
Melton Stuart L.
Shen Cecilia
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