Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsu...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S465000

Reexamination Certificate

active

10606342

ABSTRACT:
Compositions comprising bis-tetrahydrofuran benzodioxyolyl sulfonamide compounds that are surprisingly effective protease inhibitors and a second antiretroviral compound are disclosed. Methods of inhibiting retrovirus proteases, in particular multi-drug resistant retrovirus proteases, methods of treating or preventing infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication are also disclosed.

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Tomasselli et al, Targeting the HIV-protease in AIODS therapy; a current clinical perspective, Biochimica et Biophysica Acta 1477 (2000) 189-214.
Lori et al, Hydroxyurea : mechanisms of HIV-1 inhibition, PMID 10723506.
McGowan, et al, Prevention of perinatal HIV transmission during pregnancy, J. Antimicrobial Chemotherapy (200) 46, 657-6688.
Ghosh, et al., “Potent HIV Protease Inhibitors Incorporating High-Affinity P2-Ligands and (R)-(hydroxyethyl)aminosulfonamide Isostere”,Bioorg. Med. Chem. Lett., 1998, 8(6), 687-690.

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