Hexahydrodibenzofuran carboxylic acid derivatives

Details Hexahydrodibenzofuran carboxylic acid derivatives Hexahydrodibenzofuran carboxylic acid derivatives

1989-05-15

1990-09-25

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30791

Patent

active

049594850

ABSTRACT:
This invention is directed to certain dibenzofurancarboxamides and their use as 5HT.sub.3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D.sub.2 receptor binding properties. This invention also describes novel processes necessary for their preparation.

REFERENCES:
Gilman et al., I, J. A. C. S., 57, pp. 2095-99 (1935).
Gilman et al., II, J. A. C. S., 61, pp. 951-954 (1939).
Keumi et al., Fukui Daigaku Kugakubu Seni Kugyo Kenkyu Shisetsu Hokoku, 14, pp. 71-77 (1976); Chem. Abstracts, 88, 152329u (1978).
Oita et al., J. Org. Chem. 20, pp. 657-667 (1955); Chem. Abstracts, 50, 7771a-7772a (1950).

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