Hexahydroazepine, piperidine and pyrrolidine derivatives

Details Hexahydroazepine, piperidine and pyrrolidine derivatives Hexahydroazepine, piperidine and pyrrolidine derivatives

1978-11-15

1980-04-08

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265FL, 260239B, 2603268, 424244, 424267, 424274, 546222, 546236, 546240, C07D22310

Patent

active

041972414

ABSTRACT:
The invention concerns novel 2-oxo-hexahydroazepine, -piperidine and -pyrrolidine derivatives of formula (I) and their aromatized derivatives of formula (II) ##STR1## where n is 2, 3 or 4, R is hydrogen, lower alkyl or aryl(lower)alkyl, R.sup.2 is hydrogen, lower alkyl or aryl(lower)alkyl and R.sup.3 is hydrogen, lower alkyl, aryl(lower)alkyl, lower alkenyl or lower alkynyl. The compounds are useful as intermediates for preparing 3,3-disubstituted -hexahydroazepine, -piperidine and -pyrrolidine compounds having pharmacological activity, particularly analgesic activity.

REFERENCES:
Duong et al., "Australian J. Chem." (1976) vol. 29, pp. 2651-2665.
Deslongschamps et al., "Canad. J. Chem." (1975), vol. 53, pp. 1682-1683.
Hullot et al., "Canad. J. Chem." (1976), vol. 54, pp. 1098-1104.
Kugita et al., "J. Med. Chem." (1965), vol. 8, pp. 313-316.
Cavalla et al., "J. Med. Chem." (1965), vol. 8, pp. 316-326.
Tamura, "J. Med. Chem." (1970), vol. 20, pp. 709-714.

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