Hexahydroazepine, piperidine and pyrrolidine derivatives

Details Hexahydroazepine, piperidine and pyrrolidine derivatives Hexahydroazepine, piperidine and pyrrolidine derivatives

1978-11-15

1980-04-08

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603265FL, 260239B, 2603268, 424244, 424267, 424274, 546221, 546236, 546240, C07D22310

Patent

active

041972392

ABSTRACT:
The invention concerns novel 2-oxo-hexahydroazepine, -piperidine and -pyrrolidine of formula I ##STR1## where n is 2,3 or 4, R is hydrogen, lower alkyl or aryl(lower)alkyl and R.sup.1 is lower alkyl. The compounds may be aromatized and the aromatized compounds converted to 3,3-disubstituted-hexahydroazepine, -piperidine and -pyrrolidine compounds having pharmacological activity, particularly analgesic activity.

REFERENCES:
Duong et al., "Australian J. Chem." (1976) vol. 29, pp. 2651-2665.
Deslongschamps et al., "Canad. J. Chem." (1975) vol. 53, pp. 1682-1683.
Hullot et al., "Canad. J. Chem." (1976) vol. 54, pp. 1098-1104.
Kugita et al., "J. Med. Chem." (1965) vol. 8, pp. 313-316.
Cavalla et al., "J. Med. Chem." (1965) vol. 8, pp. 316-326.
Tamura, "J. Med. Chem." (1970) vol. 20, pp. 709-714.
Frostick et al., "J. Am. Chem. Soc." vol. 71 (1949) pp. 1350-1352.

Affiliated with

Also associated with

Rating

Hexahydroazepine, piperidine and pyrrolidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hexahydroazepine, piperidine and pyrrolidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hexahydroazepine, piperidine and pyrrolidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-973075