Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of

Details Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of

1996-09-25

2000-03-28

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540543, 540552, C07D26710, C07D26712, C07D26714

Patent

active

060433582

ABSTRACT:
Disclosed herein are compounds of Formula I and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of gastrointestinal motility and inflammation. These diseases and disorders include hypotension, septic shock, toxic shock syndrome, hemodialysis, IL-2 therapy such as in in cancer patients, cachexia, immunosuppression such as in transplant therapy, autoimmune and/or inflammatory indications including sunburn, eczema or psoriasis and respiratory conditions such as bronchitis, asthma, oxidant-induced lung injury and acute respiratory distress (ARDS), glomerulonephritis, restenosis, inflammatory sequelae of viral infections, myocarditis, heart failure, atherosclerosis, osteoarthritis, rheumatoid arthritis, septic arthritis, chronic or inflammatory bowel disease, ulcerative colitis, Crohn's disease, systemic lupus erythematosis (SLE), ocular conditions such as ocular hypertension, retinitis and uveitis, type 1 diabetes, insulin-dependent diabetes mellitus and cystic fibrosis.

REFERENCES:
patent: 4096140 (1978-06-01), Simpson
patent: 5854234 (1998-12-01), Hansen et al.

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