Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-06
1992-05-12
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514297, 546 93, 546 79, 546105, A61K 3137, C07D491052
Patent
active
051128292
ABSTRACT:
Novel 9-amino-1,2,3,4-tetrahydroacridines and related compounds of the formula ##STR1## wherein R.sup.1 is H, loweralkyl, or benzyl; R.sup.3 is H, loweralkyl, a group of the formula CH.sub.2 CHR.sup.2 Hal wherein R.sup.2 is hydrogen, loweralkyl, or phenyl and Hal is chloro, bromo, or iodo, or a group of the formula CHR.sup.2 CO.sub.2 R.sup.5 wherein R.sup.2 is as above and R.sup.5 is H or loweralkyl; Z is O or S; X is H, halogen, loweralkoxy, loweralkyl, or trifluoromethyl; n is 1, 2, or 3; the group ZR.sup.3 is bound to either the A- or B-position of the heteroaromatic nucleus; the pharmaceutically acceptable salts thereof; and the optical isomers thereof, useful as intermediates for the preparation of memory dysfunction relieving hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines are related compounds and for relieving memory dysfunction are disclosed.
REFERENCES:
patent: 2645594 (1953-07-01), Tabern
patent: 3232945 (1966-02-01), Sigal
patent: 3318896 (1967-05-01), Pribyl
patent: 3329676 (1967-07-01), Bell et al.
patent: 3580915 (1971-05-01), Wolf
patent: 3987047 (1976-10-01), Griss
patent: 4631286 (1986-12-01), Shutske
patent: 4695573 (1987-09-01), Shutske
patent: 4743601 (1988-05-01), Schonafinger
J. Bielavsky, Collection Czechoslav. Chem. Commun., 42, 2802 (1977).
M. E. Konshin, Khimsko-Farmatsevticheskii Zhurnal, 8, 17, (1974), translation thereof.
M. E. Konshin, Nauch. Tr. Perm. Farmatseut., In-t, 10, 6 (1976) and translation thereof.
J. F. Flood, Psychopharmacology, 86 61 (1985).
G. M. Shutske, J. Medicinal Chemistry, 32, 1805 (1989).
W. M. Cholody, Tetrahedron Letters, 28, 5029 (1987).
Kapples Kevin J.
Shutske Gregory M.
Tomer, IV John D.
Hoechst-Roussel Pharmaceuticals Inc.
Ivy C. Warren
Scalzo Catherine
Wittekind Raymond R.
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