Organic compounds -- part of the class 532-570 series – Organic compounds – 9,10-seco-cyclopentanohydrophenanthrene ring system or...
Patent
1999-08-11
2000-06-27
Dees, Jose' G.
Organic compounds -- part of the class 532-570 series
Organic compounds
9,10-seco-cyclopentanohydrophenanthrene ring system or...
C07C40100
Patent
active
060808799
ABSTRACT:
This invention provides a novel synthesis and crystallization method and solvent for producing hexafluoro-vitamin D compounds, including 26, 26, 26, 27, 27, 27-hexafluoro-1.alpha., 25-dihydroxyvitamin D.sub.3. Crystalline forms of such compounds are provided that are especially suited for pharmaceutical use. Such compounds can exhibit biological activity for treating cancers, osteoporosis and psoriasis.
REFERENCES:
patent: 4358406 (1982-11-01), DeLuca et al.
patent: 4391802 (1983-07-01), Suda et al.
patent: 4758383 (1988-07-01), Tachibana
patent: 5281731 (1994-01-01), DeLuca et al.
patent: 5726330 (1998-03-01), Mikami
patent: 5880114 (1999-03-01), DeLuca et al.
patent: 5902806 (1999-05-01), Ikeda et al.
H.E. Paaren, H.F. DeLuca and H.K. Schnoes, Direct C(1) Hydroxylation of Vitamin D3 and Related Compounds, J. Org. Chem, pp. 3253-3258 (1980).
G.-D. Zhu and W.H. Okamura, Synthesis of Vitamin D(Calciferol), Chemical Reviews, vol. 95, pp. 1877-1952 (1995).
D.D. Bikle, Clinical Counterpoint: Vitamin D: New Actions, New Analogs, New Therapeutic Potential, Endocrine Reviews, vol.13 (No. 4), pp. 765-784 (1992).
S. Jeganathan A.D. Johnston, E.A. Kuenzel, A.W. Norman and W.H. Okamura, Thermal Rearrangement of Vinylallenes; Synthesis of 3-Deoxy-1-hydroxy-14-Epiprevitamin D3, Journal of Organic Chemistry, vol. 49, pp. 2152-2158 (1984).
R. Bouillion et al., Biologic Acitivity of Dihydroxylated 19-Nor-(Pre) Vitamin D3, Journal of Bone and Mineral Research, vol. 8 (No. 8), pp. 1009-1015 (1993).
K.L. Perlman R.E. Swenson, H.E. Paaren, H.K. Schnoes and H.F. DeLuca, Novel Synthesis of 19-NOR-VITAMIN D Compounds Tetrahedron Letters, pp. 7663-7666 (1991).
Badio Barbara
Dees Jos,e G.
Tetrionics, Inc.
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