Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1989-12-27
1991-10-29
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540477, 544125, 544361, 546 41, 546 48, C97D49122, C97D31100, C97D49522
Patent
active
050617958
ABSTRACT:
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formura: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.
REFERENCES:
patent: 4939255 (1990-07-01), Tagawa et al.
Hadley, Endocrinology [Englewood Cliffs, New Jersey, 1984], p. 463.
Ejima Akio
Ohsuki Satoru
Sugimori Masamichi
Tagawa Hiroaki
Terasawa Hirofumi
Daiichi Pharmaceutical Co. Ltd.
Kabushiki Kaisha Yakul't Honsha
Shah Mukund J.
Ward E. C.
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