Hexa-cyclic camptothecin derivatives

Details Hexa-cyclic camptothecin derivatives Hexa-cyclic camptothecin derivatives

1988-06-16

1990-07-03

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540581, 544361, 544362, 544125, 546 41, 546 48, 546 51, C07D49122

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active

049392557

ABSTRACT:
A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

REFERENCES:
patent: Re32518 (1987-10-01), Miyasaka et al.
patent: 4473692 (1984-09-01), Miyasaka et al.
patent: 4513138 (1985-04-01), Miyasaka et al.
patent: 4545880 (1985-10-01), Miyasaka et al.
patent: 4604463 (1986-08-01), Miyasaka et al.
Honsha Co. Ltd., Chem. Abs., vol. 97 entry, 97: 188278b, (1982).
Organic Reactions, 28, 37-201, John Wiley & Sons, Inc. New York (1982).
C. F. Schwender et al., J. Med. Chem., 16, 254-257, (1973).
C. F. Schwender et al., J. Med. Chem., 16, 254-257, (1973).
A. Ricci et al., J. Heterocyclic Chem., 11, 515-518, (1974).

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