Hexa-arm polyethylene glycol and its derivatives and the...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S545000, C556S444000, C558S046000, C558S267000, C560S190000, C564S505000, C568S420000, C568S613000

Reexamination Certificate

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06858736

ABSTRACT:
The present invention relates to novel hexa-arm polyethylene glycol (6-arm PEG) and its derivatives. The core of 6-arm PEG derivatives is sorbitol and the end groups can be derivatized into many different reactive functionalities that are useful in conjugating with many different targets. The present invention also provides a biodegradable polymeric hydrogel-forming composition comprising the 6-arm PEG and its derivatives, and methods of using such 6-arm PEG derivatives as surgical or biological implants or sealants.

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Leach et al., “Reductionof postoperative adhesions in the rat uterine horn model with poloxamer 407,”Am J Obstet Gynecol,May 1990, pp. 1317-1319, vol. 162, No. 3.

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