Hexa- and heptapeptide anaphylatoxin-receptor ligands

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence

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530317, 530327, 514 11, 514 16, 514 17, A61K 3700, A61K 3702, C07K 500, C07K 700

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active

053876717

ABSTRACT:
Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L-M-Q are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states.
Also disclosed are anaphylatoxin receptor ligand compositions and a method for modulating anaphylatoxin activity.

REFERENCES:
Kohl et al vol. 20 Eur J Immunology pp. 1463-1468, 1990.
Hartung et al, J of Immunology vol. 130, No. 3, pp. 1345-1349, Mar. 1983.
Swerlick et al., The Journal of Immunology, vol. 140, No. 7, Apr. 1988, pp. 2376-2381.
Mollison et al, PNAS vol. 86, pp. 292-296, Jan. 1989.
T. E. Hugli, "Structure and Function of the Anaphylatoxins," Springer Seminars in Immunopathology, vol. 7 (1984).
H. P. Hartung, et al., "Induction of Thromboxane Release from Macrophages by Anaphylatoxin Peptide C3a Complement and Synthetic Hexapeptide C3a 72-77," J. Immunol., 130(3):1345-1349 (1983).
B. Weinstein, "The Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins," Marcel Dekker, New York (1983), pp. 267-277.

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