HEV orf-2 monoclonal antibodies and methods for using same

Details HEV orf-2 monoclonal antibodies and methods for using same HEV orf-2 monoclonal antibodies and methods for using same

1996-02-22

1998-11-03

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7021, 435339, 435 793, 436820, 5303883, C12Q 170, G01N 33576, C12N 1506, C07K 1610

Patent

active

058306366

ABSTRACT:
Monoclonal antibodies are described which specifically bind to Hepatitis E Virus (HEV), and more particularly to HEV orf-2 antigen. Also provided are hybridoma cell lines which secrete these monoclonal antibodies, methods for using these monoclonal antibodies, and assay kits which contain these monoclonal antibodies.

REFERENCES:
Harlow et al., Antibodies A Laboratory Manual. Cold Spring Harbor Laboratory, N.Y. 1988, pp. 567-569.
"Epitope Mapping in Proteins of Hepatitis E Virus", Y. E. Khudyakov, et al., Virology, vol.: 194, No. 1, pp. 89-96 (May 1993).
"Hepatitis E Virus (HEV): Molecular Cloning and Sequencing of the Full-Length Viral Genome", A.W. Tam, et al., Virology, vol.: 185, No. 1, pp. 120-131, (1991) New York, NY, USA.
"Human Linear B-cell Epitopes Encoded by the Hepatitis E Virus Include Determinants in the RNA-Dependent RNA Polymerase", M. Kaur, et al., Proceedings of the National Academy of Sciences of the USA, vol.: 89, No. 9, 1 May 1992 Washington, D.C.

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