Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-07
2010-12-07
Berch, Mark L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S355000
Reexamination Certificate
active
07846920
ABSTRACT:
The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of bacteria. In one embodiment, the compounds have the structure shown in formula (A) or formula (B) or formula (C):wherein the R groups are as defined in the specification. The antibacterial agents of the invention can be administered to a human or animal to treat or inhibit bacterial infection, such as that ofStaphylococcusspecies, including methicillin-resistantStaphylococcus aureus(MRSA).
REFERENCES:
patent: 3838114 (1974-09-01), Lawrence
patent: 6375926 (2002-04-01), Barnes et al.
patent: 6476015 (2002-11-01), Turos et al.
patent: 6946458 (2005-09-01), Turos
patent: 2004/0167115 (2004-08-01), Dou et al.
patent: 2007/0265243 (2007-11-01), Turos et al.
Burnett, Journal of Organic Chemistry (1986), 51(10), 1929-30.
Turos, Bioorganic & Medicinal Chemistry vol. 13, Issue 23, Dec. 1, 2005, pp. 6289-6308.
Heldreth, B., Long, T.E., Jang, S., Reddy, G.S.K., Turos, E., Dickey, S., and Lim, D.V., “N-Thiolated b-lactam antibacterials: Effects of the N-organothio substituent on anti-MRSA activity”Bioorganic&Medicinal Chemistry2006, pp. 3775-3784, vol. 14.
Kalnins, M.,“Reactions of Phthalimide and Potassium Phthalimide with Sulfur Monochloride,”Canadian Journal of Chemistry,1966, pp. 2111-2113 vol. 44.
Ren et al. “Studies on Nonconventionally Fused Bicyclic β-Lactams”J. Org. Chem., 1998 pp. 8898-8917, vol. 63.
Revell, K.D., Heldreth, B., Long, T.E., Jang, S., and Turos, E., “N-thiolated b-lactams: Studies on the mode of action and identification of a primary cellular target inStaphylococcus aureus” Bioorganic&Medicinal Chemistry, 2007, pp. 2453-2467 vol. 15.
Turos, E., Konaklieva, M.I., Ren, R.X-F., Shi, H., Gonzalez, J., Dickey, S., and Lim, D.V., “N-Thiolated Bicyclic and Monocyclic b-Lactams”Tetrahedron, 2000, pp. 5571-5578, vol. 56.
Turos, E., Long, T.E., Heldreth, B., Leslie, J.M., Reddy, G.S.K., Wang, Y., Coates, C., Konaklieva, M., Dickey, S., Lim, D.V., Alonso, E., and Gonzalez J., “N-Thiolated b-lactams: A new family of anti-Bacillus agents”Bioorganic&Medicinal Chemistry Letters, 2006, pp. 2084-2090, vol. 16.
Turos, E., Shim, J., Wang, Y., Greenhalgh, K., Reddy, G.S.K., Dickey, S., and Lim, D.V., “Antibiotic-conjugated polyacrylate nanoparticles: New opportunities for development of anti-MRSA agents”Bioorganic&Medicinal Chemistry Letters, 2007, pp. 53-56, vol. 17.
Ramaraju Praveen
Turos Edward
Berch Mark L
Saliwanchik Lloyd & Saliwanchik
University of South Florida
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