Heteromorphic sponges containing active agents

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

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514773, 514774, 514777, 514781, 604359, 604360, 604364, 604368, 604379, A61F 202, A61F 1315, A61F 1320, A61K 4742

Patent

active

057004765

ABSTRACT:
The invention provides wound dressing and/or implant materials comprising a matrix structure of sponge, at least one substructure and at least one pharmacologically active agent, wherein both the matrix structure and the substructure are formed from bioabsorbable biopolymer materials. The substructure may, for example, comprise biopolymer films, flakes, fibres or microspheres embedded in the matrix structure of sponge. The pharmacologically active agent may comprise antiseptics, antibiotics, analgesics. One or more such active agents may be incorporated separately into the matrix and/or the substructure so as to achieve controlled or phasic release of the active agents into the wound.

REFERENCES:
patent: 3823212 (1974-07-01), Chvapil
patent: 4233360 (1980-11-01), Luck et al.
patent: 4320201 (1982-03-01), Berg et al.
patent: 4614794 (1986-09-01), Easton et al.
Collagen Sponge: Theory and Practice of Medical Applications; J. Biomed. Mater. Res; vol. 11, pp. 721-741 (1977); Milow Chvapil.
Design of an Artificial Skin. I. Basic Design principles; Journal of Biomedical Materials Research, vol. 14, 65-81 9 I.V. Yannas and John F. Burke.
EPO Search Report in EP 93 30 2319, a corresponding foreign application.

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