Heterologous protection induced by immunization with...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Reexamination Certificate

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C424S234100, C530S825000

Reexamination Certificate

active

10150814

ABSTRACT:
In this application is described a composition, Invaplex, derived from a gram negative bacteria for use in generating an immune response in a subject against one or more heterologous species or strains of gram-negative bacteria.

REFERENCES:
patent: 6245892 (2001-06-01), Oaks
patent: 6248329 (2001-06-01), Chandrashekar et al.
patent: 6277379 (2001-08-01), Oaks et al.
patent: WO 00/18354 (2000-04-01), None
Turbyfill et al., Infection and Immunity vol. 68, No. 13, pp. 6624-6632, Dec. 2000.
Alexander et al (Vaccine , 14(11):1053-1061, 1996).
Ellis, R.W. (Chapter 29 in “VACCINES” Plotin, S.A. et al eds, W. B Saunders Co., Philadelphia, PA, 1988, p. 571, second full paragraph.
Jennison et al, FEMS Microbiological Reviews, 28:43-58, 2004.
Charkrabarti et al (Acta Paediatr, 88:161-5, 1999).
Turbyfill et al. (1998) Identification of Epitope and Surface-Exposed Domains ofShigella flexneriInvasion Plasmid Antigen D (IpaD).Infection and Immunity66, 1999-2006.
Barzu et al. (1996) Induction of a Local Anti-IpaC Antibody Response in Mice by Use of aShegella flexneri2a Vaccine Candidate: Implications for Use of IpaC as a Protein Carrier.Infection and Immunity64, 1190-1196.
Turbyfill et al, “Isolation and Characterization of theShigellaInvasin Complex and Use as a New Subunit Vaccine,” Abstracts of the General Meeting of the American Society for Microbiology, vol. 99, May 30, 1999, p. 291.
Oaks et al, “Evaluation of theShigellaInvasin Complex and Purified IpaC as Mucosal Adjuvants,” Abstracts of the General Meeting of the American Society for Microbiology, vol. 99, 1999, p. 282.

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