Heterologous production of polyketides

Details Heterologous production of polyketides Heterologous production of polyketides

2006-03-14

2006-03-14

Kerr, Kathleen (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S252330

Reexamination Certificate

active

07011959

ABSTRACT:
RecombinantE. colihost cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase fromPropionibacterium shermaniiorStreptomyces cinnamonensisas well asPropionibacterium shermaniiepimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-typeE. colihost cells.

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