Heterogenous chemiluminescent specific binding assay

Details Heterogenous chemiluminescent specific binding assay Heterogenous chemiluminescent specific binding assay

1979-06-21

1983-04-19

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436500, 436518, 436532, 436805, 436817, 436818, 422 61, G01N 3354, G01N 3358, G01N 2176

Patent

active

043805809

ABSTRACT:
A heterogeneous specific binding assay which employs a substance having reactant activity, i.e., a reactant, in a chemiluminescent reaction as a labeling substance in the detection of a ligand in a liquid medium. The method is carried out using reagent means which comprises, as its labeled constituent, a conjugate formed of a specific binding substance coupled to the chemiluminescent reactant. The activity of the conjugated reactant in the chemiluminescent reaction, i.e., the production of light, is utilized as means for monitoring the extent of binding of the labeled constituent in conventional heterogeneous specific binding assay schemes. The presence of a ligand in a liquid medium may be determined following conventional competitive binding manipulative techniques. After the necessary separation of the bound- and free-phases resulting in the specific binding reaction system, the extent of binding of the labeled constituent is determined by contacting either phase with the necessary materials to form the chemiluminescent monitoring reaction and measuring the light produced.

REFERENCES:
patent: 4011219 (1977-03-01), Nishii
patent: 4104029 (1978-08-01), Maier
patent: 4181650 (1980-01-01), Maier

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